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As additive manufacturing becomes an increasingly popular method for advanced manufacturing of components, there are many questions that need to be answered before these parts can be implemented for structural purposes. One of the most common concerns with additively manufactured parts is the reliability when subjected to cyclic loadings which has been shown to be highly sensitive to defects such as pores and lack of fusion between layers. It stands to reason that larger parts will inherently have more defects than smaller parts which may result in some sensitivity to surface area differences between these parts. In this research, Ti-6Al-4V specimens with various sizes were produced via a laser-based powder bed fusion method. Uniaxial fatigue tests based on ASTM standards were conducted to generate fatigue-life curves for comparison. Fractography on the fractured specimens was performed to distinguish failure mechanisms between specimen sets with different sizes.